DNA Metafiles 1.0 Description:

The molecular structure of DNA (deoxyribonucleic acid) was first
described by Watson and Crick in 1953.

Basically, the DNA structure is comprised of two anti-parallel
polynucleotide chains arranged in a double helix. The phosphate
and sugar backbones are on the outside of the molecule with
the bases pointing inward. Adenine (A) and guanine (G) residues
on one chain pair via hydrogen bonding to thymine (T) and
cytosine (C) residues, respectively, on the opposite chain.

The precise arrangement of A, G, T, and C bases along each chain
effectively codes the genetic information contained in each
cell and provides a means to transfer this information to
offspring. Watson and Crick received the Nobel Prize for their
discovery.

DNA Metafiles will illustrate the DNA's molecular structure in the following
Windows metafiles -- carbon (black), nitrogen (blue),
oxygen (red), and phosphorus (yellow):

A_DNA.wmf
This is the more compact arrangement of DNA. The most striking
features of the A-DNA structure are the relatively high
high tilt of the bases (20°) and the narrowness and small
depth of the grooves.

A_DNA_1.wmf
The binding sites for cations, such as sodium, between adjacent
phosphate groups along each chain are illustrated (pink).
These sites were first described by the author as part of his
doctoral thesis in 1977.

B_DNA.wmf
The base pairs are nearly perpendicular to the helix axis, and
there are two distinguishable grooves, one much wider and
deeper than the other. These major and minor grooves may
provide a site for DNA-protein interactions.

dT_dA_dT.wmf
This synthetic triple helix is comprised of a single
polydeoxyriboadenosine chain and two polydeoxyribothymine
chains. It exhibits an A-type structure.

poly_A.wmf
Synthetic polyriboadenosine demonstrates that the helical
structure of polyribonucleotides is inherent even for single-
stranded molecules.

polydAdT.wmf
This synthetic double helix is comprised of
polydeoxyriboadenosine and polydeoxyribothymine chains. It
exhibits a B-type structure.

Related searches:

dna - structure synth

DNA Metafiles security information

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