MedCalc 10.3.0.0 Description:

MedCalc is a useful and stand-alone computer software for statistics in the biomedical sciences. It has an integrated spreadsheet which can be configured to contain up to 520 columns and 32766 rows.

MedCalc correctly handles missing data and provides reliable date arithmetic. MedCalc can import Excel, SPSS, DBase and Lotus files, and files in SYLK, DIF or text format.

Comprehensive on line help is available and, in addition to a manual in PDF format, a complete user manual is available on the web.

Special features of the program are, amongst others, lots of graphs including Kaplan-Meier survival plots, Bland & Altman plot, Deming and Passing & Bablok regression for method comparison.

MedCalc also includes a complete module for Receiver Operating Characteristic (ROC) curve analysis, with calculation of sensitivity, specificity, likelihood ratios, and positive and negative predictive values for all possible threshold values.

MedCalc calculates the area under the curve (AUC) with its standard error and 95% confidence interval.

Furthermore, threshold values can be selected in an interactive dot diagram with automatic calculation of corresponding sensitivity and specificity.

Comparison of ROC curves includes calculation of the difference between the areas under the curves, with standard error, 95% confidence interval and P-value.

MedCalc 10.3.0.0 Features:

Data management
· Integrated spreadsheet with up to 676 columns and 100000 rows.
· Correct handling of missing data.
· Outliers can easily be excluded [Example].
· Built-in WYSIWYG text editor.
· Imports Excel, SPSS, DBase and Lotus files, and files in SYLK, DIF or plain text format.
· Easy selection of subgroups for statistical analysis.

Documentation
· Comprehensive help file.
· Manual in PDF format (go to download area).
· Complete HTML manual on MedCalc web site.
· Context help in dialog boxes.

ROC curve analysis
· Area under the curve (AUC) with standard error, 95% confidence interval, P-value.
· List of sensitivity, specificity, likelihood ratios, and positive and negative predictive values for all possible threshold values.
· ROC curve graph with 95% Confidence Bounds.
· Threshold values can be selected in an interactive dot diagram with automatic calculation of corresponding sensitivity and specificity.
· Plot of sensitivity and specificity versus criterion values.
· Comparison of up to 6 ROC curves: difference between the areas under the ROC curves, with standard error, 95% confidence interval and P-value.
· Sample size calculation for area under ROC curve and comparison of ROC curves.
· Go to the ROC curve analysis section of the MedCalc manual for more information on ROC curve analysis in MedCalc.

Graphs
· Lots of graphs, see Graph gallery.
· Data point identification in graphs
· Name, save and recall graphs and statistics
· Statistical info in graph windows

MedCalc 10.3.0.0 Requirements:

· 8 Mb free space on the hard disk.
· 64 MB RAM.

MedCalc 10.3.0.0 Limitations:

· The demo version can be used 25 times
· The data you enter cannot be saved
· The spreadsheet is limited to 26 columns and 182 rows
· You cannot export or save graphs

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